We believe diet and nutrition are a factor
The food we eat has a major impact on our health. The cause of H-abc/Tubb4a related leukodystrophy has never been explained and we believe diet and nutrition may help. Although mutations are typically de novo (occurring immediately following conception) the mutations are tied to error during DNA replication. DNA damage can be triggered by ionizing radiation, oxidating stress (from metabolic or external pollutants) or chemical exposure.
The following is for informational purposes only and should not be construed as medical advice. Please consult a medical professional or healthcare provider before considering any changes to your diet, nutritional plan or use of any supplements.
Since no cure currently exists, treatments focus on symptom management, and there are limited studies on natural remedies specifically for the condition. However, some supportive strategies may help improve quality of life and support general neurological health. We will add to this as we gain additional insight.
Dietary Approaches
• Anti-inflammatory Foods: Diets rich in antioxidants may help reduce oxidative stress and inflammation, potentially beneficial for neurodegenerative conditions. Include: • Fruits like berries (blueberries, strawberries) • Vegetables like spinach, kale, and broccoli • Omega-3 fatty acids from fish, flaxseeds, or walnuts • Ketogenic Diet: In some neurological disorders, ketogenic diets have been shown to improve brain function. Consult a specialist to evaluate its suitability for the condition. • Stick with non processed foods and foods with low / no additives and or pesticides, antibiotics or other non organic agents.
L-Serine Supplementation • L-serine, a naturally occurring amino acid, has shown promise in some neurodegenerative disorders. Though its effectiveness in this condition isn’t established, its role in cell repair and neurotransmitter support may warrant exploration with a healthcare provider.
Herbal and Nutritional Supplements: • Turmeric/Curcumin: A natural anti-inflammatory compound that might reduce neuroinflammation. • Vitamin D and B-Complex Vitamins: Important for neurological health and might help with muscle and nerve function. • Magnesium: May assist with muscle relaxation and spasticity management. • CoQ10 plays an essential role in energy production • Alpha-lipoic acid is an antioxidant • N-acetyl cysteine (NAC) protect the cells from oxidative stress • Phospholipids fats are essential to mitochondria membrane • Carnitine which is an amino acid helps tranport fatty acids necessary for cell energy production
Hydration and Electrolyte Balance: • Proper hydration and balanced electrolytes can support nerve and muscle function, particularly in managing spasticity.
Stress Management and Relaxation: • Techniques like mindfulness, meditation, or massage therapy can help reduce stress, which might exacerbate symptoms.
ABOUT MYELIN
Myelin growth is a material factor for those living with this condition. Consider the following, again under guidance from your healthcare provider:
1. Essential Nutrients for Myelin Growth
Healthy Fats (Essential for Myelin Sheath Structure)
• Omega-3 Fatty Acids – Found in fatty fish (salmon, sardines, mackerel), flaxseeds, chia seeds, and walnuts.
• Phospholipids – Found in eggs, soy lecithin, and sunflower lecithin.
• Saturated Fats & Cholesterol – Found in grass-fed butter, ghee, coconut oil, and organic eggs (cholesterol is a key component of myelin).
B Vitamins (Critical for Myelin Production)
• B12 (Methylcobalamin) – Found in grass-fed meat, wild-caught fish, eggs, and dairy. Deficiency leads to demyelination.
• B1 (Thiamine) – Found in pork, nuts, whole grains. Important for nerve function.
• B6 (Pyridoxine) – Found in bananas, poultry, and potatoes. Supports neurotransmitter production.
• B9 (Folate, preferably methylfolate) – Found in leafy greens, asparagus, and avocado. Essential for methylation.
Other Key Nutrients
• Vitamin D – Supports immune function and myelin maintenance (sun exposure, fatty fish, fortified foods).
• Choline – Essential for acetylcholine production and myelin integrity (egg yolks, liver, cruciferous vegetables).
• Zinc & Magnesium – Involved in nerve function and repair (pumpkin seeds, nuts, dark chocolate, leafy greens).
• Iron – Important for oligodendrocyte function (grass-fed red meat, spinach, lentils).
2. Supplements for Myelin Repair & Neuroprotection
If diet alone isn’t sufficient, targeted supplementation can help:
• Omega-3 Fish Oil (EPA/DHA) – Supports myelin repair and neuroprotection.
• Phosphatidylserine & Phosphatidylcholine – Found in soy lecithin or sunflower lecithin; helps rebuild myelin.
• Lion’s Mane Mushroom – Promotes nerve growth factor (NGF) and neurogenesis.
• N-Acetyl Cysteine (NAC) – Boosts glutathione levels and protects nerve cells.
• Alpha-Lipoic Acid (ALA) – Reduces oxidative stress and supports nerve repair.
• Acetyl-L-Carnitine (ALCAR) – Supports mitochondrial function and nerve regeneration
• Methylcobalamin (Active B12) & Methylfolate (B9) – Essential for myelin production.
• Vitamin D3 + K2 – Supports immune function and nerve health.
3. Lifestyle Strategies to Promote Myelin Regeneration
• Intermittent Fasting – Promotes autophagy, helping remove damaged cells and stimulate new myelin growth.
• Exercise (Especially Resistance & Aerobic) – Increases brain-derived neurotrophic factor (BDNF), essential for nerve growth.
• Deep Sleep – Essential for myelin repair; prioritize 7–9 hours of quality sleep.
• Brain Stimulation (Learning New Skills) – Engaging in cognitive challenges can increase oligodendrocyte activity.
• Reduce Chronic Stress – High cortisol levels can damage myelin. Try meditation, yoga, etc
Important Notes • Consultation is Crucial: Natural remedies should always be considered as complementary to medical treatment. Consult a neurologist or specialist familiar with leukodystrophies before starting any supplement or therapy. • Safety First: Be cautious with supplements, as some may interact with medications or have unintended side effects in rare conditions like H-ABC.